|
KMID : 1161420110140070857
|
|
Journal of Medicinal Food
2011 Volume.14 No. 7 p.857 ~ p.865
|
|
|
Tryptophan Supplements Promote Pregnancy Success in Mice Challenged with Pseudorabies Virus (PRV) by Regulating the Expression of Systemic Cytokines, Immunoglobulins, PRV-Specific Protein Profiles, and Toll-Like Receptors
|
|
Qiu Shixiu
Fang Zhengfeng
Wu De
Lin Yan
Che Lianqiang
|
|
|
Abstract
|
|
|
|
Tryptophan (Trp) plays an important role in regulating the maternal immune response, a key determinant of the success or failure of pregnancy, but whether Trp supplements can prevent a pseudorabies virus (PRV)-induced failure of pregnancy remains unknown. This study examined the effect of three dietary Trp levels (0.25%, 0.35%, and 0.5%) on the immunity and reproduction of PRV-challenged pregnant mice. PRV challenge resulted in decreased live embryo numbers, live litter sizes, and serum progesterone and interleukin (IL)-10 concentrations, but increased the levels of serum immunoglobulins (Igs) (PRV-specific antibody [IgG, IgA, and IgM]) and IL-1β. Live embryo numbers, live litter sizes, serum progesterone concentration, and IgG and PRV-specific antibody levels on day 9 of pregnancy were all increased dose-dependently by Trp inclusion in the diet of PRV-challenged mice. Increased Trp levels in PRV-challenged mice promoted the up-regulation of uterine and embryonic indoleamine 2,3-dioxygenase expression, but attenuated the up-regulation of uterine and embryonic Toll-like receptor (TLR) 3 and TLR9 expression and increased serum interferon-γ concentration. Collectively, Trp supplements might improve reproductive performance of PRV-challenged pregnant mice by down-regulating TLR expression and pro-inflammatory cytokine synthesis, by up-regulating PRV-specific antibody and immunoglobulin synthesis, and by elevating the concentrations of anti-inflammatory cytokines and progesterone.
|
|
|
KEYWORD
|
|
|
cytokines, immunoglobulins, pregnancy, pseudorabies virus, Toll-like receptors, tryptophan
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|